The journal Nutrients published the results of a study indicating that the amino acid L-citrulline found in watermelon can boost the production of nitric oxide, a key molecule that regulates blood vessel tension and reduces the risk of cardiovascular disease.
Scientists explained that L-citrulline, found in watermelon pulp and rind, increases blood levels of L-arginine, which in turn boosts nitric oxide synthesis. Nitric oxide dilates blood vessels, improves blood flow, and lowers blood pressure. Unlike consuming L-arginine directly, L-citrulline is not metabolized in the liver, making it a more effective and safer source for supporting cardiovascular health.
The researchers noted that despite the promising results, the amount of L-citrulline in fresh watermelon is limited, and to reach the minimum effective dose, one would need to consume kilograms of pulp or rind. Therefore, watermelon concentrates, powders, and new forms of natural remedies derived from this fruit are emerging as promising options, allowing for high doses of the active ingredient without excessive fruit consumption.
Scientists stressed the need for long-term clinical trials, especially on people at risk of cardiovascular disease, to determine optimal doses and confirm L-citrulline's ability to improve blood pressure, blood vessel elasticity, and the function of the lining of arteries and veins.
