The press office of Yaroslavl State Technical University explained that the scientists' discovery could form the basis for developing a new generation of antibiotics. The university has developed innovative derivatives of the compound "spirocromoprimidine," capable of eliminating pathogens resistant to current antibiotics and slowing cell aging, in addition to possessing antioxidant properties.
According to Galina Repina, director of the Institute of Chemistry and Chemical Technology at the university, the manufactured compounds showed strong antibacterial activity and also had superior antioxidant properties.
Pharmacokinetic analysis of the compounds revealed favorable drug-like properties, including high absorption from the gastrointestinal tract and the ability to penetrate the blood-brain barrier.
The new compounds could contribute to future developments in the treatment of infectious diseases and disorders associated with oxidative stress. This scientific research was conducted at Yaroslavl University in collaboration with the Moscow Institute of Physics and Technology and the Pharmaceutical Technology Transfer Center at Yaroslavl State Pedagogical University.
Scientists have prepared these compounds and studied their structure in detail. Initial tests have helped assess their activity against a range of bacterial strains, while modeling has revealed the potential impact on the human body.