Villa managed to hold the Gunners to a draw in the first half, but the home side went on a rampage in the second half.
Gabriel's goal opened Arsenal's scoring account in the 48th minute with a header from a corner. Arsenal then added three more goals through Martin Zubimendi (52'), Leandro Trossard (69'), and Gabriel Jesus (78').
The visitors, who had beaten Arsenal at Villa Park three weeks ago, could only manage a consolation goal through Ollie Watkins in the 90+4th minute.
Arsenal have now won six straight matches in all competitions since their defeat at Villa Park, while Villa saw their 11-match winning streak come to an end.
