A new study has revealed that tirzepatide, the active ingredient in the popular weight-loss injection Mangaro, may significantly reduce the risk of heart attacks.
American researchers found that people who used this injection were 33% less likely to have a heart attack compared to other patients taking another drug to treat type 2 diabetes.
Previous studies had suggested that semaglutide, the active ingredient in the Wegovi and Ozempic injections, could reduce the risk of serious heart problems, regardless of how much weight patients lost. But this is the first time evidence has also indicated that Mangaro injections may have the same effect.
During the study, researchers from Harvard University in Boston tracked data from nearly 53,000 people with type 2 diabetes and heart disease who started taking either Manjaro or sitagliptin (another diabetes medication). They analyzed major adverse cardiovascular events, including heart attacks, strokes, and death from any cause, between the two groups.
After one year, the risk of adverse cardiac events was 2.9% among Manjaro users, compared to 4.4% in the sitagliptin group. Researchers estimate this equates to preventing one event for every 70 people.
Manjaro reduced the risk of heart attacks by a third, although there was no statistically significant difference in stroke cases. It also reduced hospital admissions due to infections, preventing one admission for every 48 patients, and one death from any cause for every 122 patients.
The researchers wrote in The BMJ: "This study shows how evidence based on clinical trials can estimate the expected cardiovascular benefit of initiating terzepatide in addition to standard baseline therapy, and inform joint decision-making."
It is worth noting that currently, general practitioners can prescribe Mangaro for weight loss to patients whose weight poses a significant risk to their health. This includes those with a body mass index (BMI) of 40 or higher (or 37.5 if they are from a minority ethnic background) and who suffer from four weight-related health conditions, including: high cholesterol, high blood pressure, prediabetes, type 2 diabetes, obstructive sleep apnea, and heart disease.
