A blocked nose can cause difficulty breathing and sleeping, and the discomfort increases when it lasts for a long time and does not respond to usual treatments.
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In this context, a recent clinical study tested a new drug combination to see if it could relieve symptoms without causing congestion to return after stopping treatment.
The study showed that combining oxymetazoline, a decongestant spray, with budesonide, a nasal corticosteroid (a nasal spray containing a drug similar to the hormone cortisol produced by the adrenal gland, which reduces inflammation and swelling inside the nose), may be more effective in relieving chronic nasal congestion than using budesonide alone, without any signs of rebound congestion appearing during the trial period
It is the return or worsening of nasal congestion after excessive use of decongestant sprays, which may prompt the patient to use them more, thus entering a vicious cycle of temporary improvement followed by renewed congestion.
The trial involved 60 adults with chronic nasal congestion who had previously tried conventional steroid nasal sprays without sufficient improvement. Participants were randomly divided into two groups:
- One group received the combination inhaler that combines oxymetazoline with budesonide.
- Another group received budesonide only.
The participants used the treatment twice daily for four weeks, then the doses were gradually reduced over three weeks, with the aim of seeing if stopping oxymetazoline would cause the congestion to return.
After two weeks, the combination therapy group showed a greater reduction in nasal obstruction severity, and this advantage persisted until the end of the fourth week. After four weeks:
The study also showed that patients who used the combination inhaler tolerated the dose reduction and then the cessation of oxymetazoline without a significant deterioration in their condition.
The results suggest that this drug combination may be a promising option for patients with chronic nasal congestion who do not respond well to traditional treatments. However, the researchers emphasized that further long-term studies are needed to confirm the absence of rebound congestion.
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