This serum is based on a precise scientific formula that includes caffeine and panthenol (a common moisturizer in hair care products), in addition to two protein growth factors: fibroblast growth factor 7, which maintains hair-producing cells, and insulin-like growth factor 1, which stimulates the development of hair follicles.
But the most exciting component in this formula is the extracellular vesicles extracted from the Centella asiatica plant, also known as the Indian navel and the Asian navel. These are tiny, bubble-like vesicles naturally produced by plant cells that contain proteins, lipids, and genetic information that act as biochemical messengers.
To test the effectiveness of this serum, the research team conducted a 56-day clinical trial involving 60 healthy male and female volunteers who did not suffer from baldness.
The participants were divided into five groups, each of which took a different formulation: one group took a placebo, another used the basic formulation (caffeine and panthenol only), a third group had synthetic growth factors added to it, a fourth group had plant cells added to it, while the fifth group used the complete formulation that combined all the previous components.
The results, published in the journal medRxiv, showed the complete formula to be clearly superior to all other options. After just eight weeks of daily use, users of the complete formula experienced a 101% increase in hair thickness compared to the placebo group, and hair density also increased by a similar percentage. In practical terms, these participants gained an additional 3.5 centimeters of hair length during the short study period.
The improvements were not limited to hair growth, but also included overall scalp health, with hair loss decreasing by 47% and sebum secretion decreasing by 25% compared to the placebo group.
In measuring these results, the researchers relied on advanced tools including digital microscopes equipped with artificial intelligence to count hairs and measure their thickness, special devices to analyze scalp oiliness, in addition to precise combing tests in which the fallen hairs were collected and counted.
However, the researchers caution that while this study shows promising results, it has some limitations. First, the trial included healthy volunteers without hereditary baldness, so the findings cannot be generalized to people with advanced forms of hair loss. Second, the short study period (56 days) did not allow for observing the complete hair growth cycle, which can extend over years, and therefore the long-term sustainability of the results cannot be determined. Third, the majority of participants were young women (80%, with an average age of 36), limiting the applicability of the results to men or older age groups, as hair loss patterns differ and follicle regeneration capacity decreases with age. Fourth, the small sample size (12 people in each group) makes it difficult to conduct accurate sub-analyses or detect rare side effects
Analyzing the contribution of each component individually, growth factors proved to be the most influential, leading to a 67% increase in hair thickness and a 95% increase in density. The base formula (caffeine, panthenol, and plant extracts) achieved improvements ranging from 45% to 70%. However, combining all these ingredients into a single formula produced the strongest synergistic effect, highlighting the importance of a holistic approach to treating hair problems.
The new method, which combines the natural communication signals of plants with lab-made growth factors, represents an innovative approach that goes beyond traditional treatments that rely on single components
However, the researchers caution that while this study shows promising results, it has some limitations. First, the trial included healthy volunteers without hereditary baldness, so the findings cannot be generalized to people with advanced forms of hair loss. Second, the short study period (56 days) did not allow for observing the complete hair growth cycle, which can extend over years, and therefore the long-term sustainability of the results cannot be determined. Third, the majority of participants were young women (80%, with an average age of 36), limiting the applicability of the results to men or older age groups, as hair loss patterns differ and follicle regeneration capacity decreases with age. Fourth, the small sample size (12 people in each group) makes it difficult to conduct accurate sub-analyses or detect rare side effects
Finally, it should be noted that the research was funded by the same company that produces the serum, which necessitates future independent studies to confirm the results.
The researchers confirmed that the funding company did not interfere in the analysis of the data or the interpretation of the results, but this funding remains a factor to be considered when evaluating the study.
Despite these reservations, the study offers hope for the development of more effective hair loss treatments and underscores the importance of combining natural ingredients with modern science in addressing health and cosmetic challenges. Researchers look forward to conducting more comprehensive and longer-term studies in the future, involving diverse patient groups and providing a clearer picture of the potential of this promising treatment
