Russia develops a unique cellular model to identify the causes of infertility
Researchers from Moscow State University and the Institute of Growth Biology of the Russian Academy of Sciences have created a unique cell line capable of mimicking the development of diseases such as polycystic ovary syndrome and identifying the causes of these disorders.
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The university's media office stated that this achievement will facilitate the development of new reproductive technologies.
This cell line allows for the study of the early stages of ovarian follicle development, stages that are difficult for scientists to replicate in the lab because these cells lose their characteristics and ability to divide rapidly outside the body. Currently used "immortal" cell lines in research are usually derived from tumors, which can distort the hormonal response.
A source at the university explained: "The researchers were able to overcome these limitations by creating a stable cell lineage. To achieve this, primary granulosa (follicular) cells isolated from mouse ovarian follicles were modified by inserting the human telomerase gene , allowing the cells to exceed the mitotic limit while maintaining their normal shape and basic functional properties."
This new system allows for the study of ovarian follicle maturation and more accurate drug testing.
The media office confirmed that these cells respond appropriately to hormonal stimulation and can mimic pathological conditions such as polycystic ovary syndrome , making the creation of such cellular systems an important step towards developing next-generation reproductive technologies.
The results of this study are published in the journal Cells
