For the first time, Japanese scientists have succeeded in growing pituitary gland tissue from human stem cells and successfully transplanting it into the bodies of primates (macacas monkeys) after removing their natural glands.
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Researchers grew pituitary gland-mimicking organoids using human embryonic stem cells, initially testing them on mice before moving on to macaques. Follow-up medical investigations revealed the following results:
Sustained vital function: The cultured organ continued to function efficiently within the monkeys' bodies for 6 weeks, raising levels of adrenocorticotropic hormone (ACTH) and cortisol, as well as slowing weight loss associated with hormonal deficiency.
Tissue integrity: Three months after the operation, tests confirmed that the cultured cells remained alive, with the lungs and liver completely free of any "stray" or migrating cells.
Long-term safety: Preliminary experiments on mice showed that the organelles continued to function for more than 6 months without any cancerous activity or tumor formation being recorded.
The importance of this success lies in the vital role played by the pituitary gland, which secretes the hormone (ACTH) responsible for sending signals that stimulate the adrenal glands to produce cortisol (the stress hormone).
The absence of this dynamic regulation leads to the body's inability to cope with stress, posing a high risk that may end in sudden death in severe cases.
Patients with damage to or insufficiency of the pituitary gland are currently forced to take hormone drugs for life; these are uncomfortable alternatives that cannot mimic the natural, flexible response that accurately adapts to the body's changing needs.
classify this experiment as the first successful transplantation of human pituitary cells into a primate.
This achievement opens the door in the future to the development of personalized and customized treatment strategies that allow for the repair of pituitary gland disorders using stem cells derived from the patient himself, which may end the era of permanent dependence on alternative medicines.
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