This meeting between the two Premier League teams is predicted to be the most exciting match, considering that both are top seeds and have big ambitions to go far in England's oldest competition.
Manchester City will travel to Newcastle's headquarters in a match that is sure to be tight.
In addition to that match, the spotlight is also on Wrexham, who will host Chelsea. The club, owned by Hollywood actor Ryan Reynolds, advanced to the fifth round for the first time since 1997 after eliminating Ipswich Town.
A tough challenge awaits Wrexham as they face Chelsea, who previously won 4-0 against Hull City.
In another match, Arsenal, who are currently leading the English Premier League standings, will visit the headquarters of League One team, Mansfield Town.
