Scientists at the University of Bonn have conducted a successful experiment to convert the blood cells of an 80-year-old donor into neural stem cells while controlling their age.
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Scientists from the University Hospital and the University of Bonn have successfully rejuvenated human cells in the laboratory, reducing the molecular age of cells from an 80-year-old donor to less than 20 years. This discovery allows for a deeper understanding of the mechanisms of aging and may help in combating neurodegenerative diseases.
Researchers have reprogrammed red blood cell precursors into neural stem cells, bypassing the pluripotent stem cell stage, allowing them to observe the gradual regeneration process as the cells' genetic "clock" was reset over a period of more than 100 days. This provides a suitable model for studying the factors that influence the rate of aging.
The researchers measured the effect by observing epigenetic changes in DNA, which reflect a cell's age without altering the genetic information itself. The "rejuvenated" cells were found to behave much like younger cells.
Scientists hope this model will help identify substances capable of regulating the regeneration process, which is crucial, as aging remains the main risk factor for diseases such as Alzheimer's.
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